About Help FAQ

Symbol
Name
ID

Tlr7
toll-like receptor 7
MGI:2176882

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Severe viral infection	Severe SARS-CoV-2 infection
Disease(s) Associated with TLR7	Severe viral infection	Severe SARS-CoV-2 infection
X-Linked immunodeficiency 74

Mouse Phenotypes

decreased B cell apoptosis

decreased B cell proliferation

decreased splenocyte proliferation

increased splenocyte proliferation

salivary gland inflammation

pancreas inflammation

enlarged spleen

spleen hyperplasia

increased germinal center B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased mature B cell number

increased marginal zone B cell number

increased plasma cell number

increased B cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased T follicular helper cell number

increased CD4-positive, alpha-beta T cell number

decreased leukocyte cell number

abnormal dendritic cell morphology

abnormal B cell morphology

abnormal mature B cell morphology

abnormal spleen morphology

increased spleen germinal center number

decreased spleen white pulp amount

abnormal B cell physiology

abnormal B cell activation

decreased IgG1 level

decreased IgG2a level

decreased IgG level

decreased IgM level

abnormal T cell activation

abnormal macrophage physiology

abnormal circulating chemokine level

decreased circulating interferon-alpha level

increased circulating interferon-gamma level

increased circulating interleukin-10 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal Peyer's patch morphology

abnormal dendritic cell physiology

abnormal plasmacytoid dendritic cell physiology

lymph node inflammation

decreased interferon-alpha secretion

decreased interleukin-12b secretion

decreased tumor necrosis factor secretion

autoimmune response

increased susceptibility to systemic lupus erythematosus

decreased anti-insulin autoantibody level

increased autoantibody level

increased anti-nuclear antigen antibody level

increased anti-double stranded DNA antibody level

increased anti-single stranded DNA antibody level

increased inflammatory response

liver inflammation

glomerulonephritis

lung inflammation

Availability

Mouse Genotype

Tlr7^em2Anu/Tlr7^em2Anu

Tlr7^rsq1/Tlr7^rsq1

Tlr7^tm1Aki/Tlr7^tm1Aki

Tlr7^tm1Flv/Tlr7^tm1Flv

Tlr8/Tlr7^tm1Vlcg/Tlr8/Tlr7^tm1Vlcg

Tlr7^em2Anu/Tlr7⁺

Tlr7^em2Anu/Y

Tlr7^rsq1/Y

Tlr7^rsq2/Y

Tlr7^tm1Flv/Y

X/Tg(Tlr7)6Boll

Tg(Tlr7)1Boll/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23